【佳学基因检测】阿片类药物成瘾、遗传易感性和药物治疗：综述

神经病基因检测有用吗分析

分析精神病分子诊断与基因分析了解《Int J Mol Sci》在. 2019 Sep 2;20(17):4294.发表了一篇题目为《阿片类药物成瘾、遗传易感性和药物治疗：综述》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Shao-Cheng Wang, Yuan-Chuan Chen, Chun-Hung Lee, Ching-Ming Cheng等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及正确治疗临床研究内容关键词：

精神科心理科疾病用药指导基因检测临床应用结果

阿片类药物成瘾是一种以反复和缓解为特征的慢性复杂疾病。在过去的十年中，美国的阿片类药物流行或阿片类药物危机已经提高了公众的认识。美沙酮、丁丙诺啡和纳洛酮已证明它们在治疗成瘾者方面的有效性，它们各自对不同的阿片受体有不同的作用。经典和分子遗传学研究提供了有价值的信息，并揭示了阿片类药物成瘾易感性个体差异的可能机制。基于全基因组关联研究 (GWAS) 结果的多基因风险评分可能是评估整个基因组中表型和遗传标记之间关联的有前途的工具。一种新的基因编辑方法，即成簇的、规则间隔的短回文重复序列 (CRISPR)，已广泛用于基础研究，并可能应用于精神疾病等人类治疗；目前正在研究许多基于 CRISPR 的成瘾应用，其中一些在动物研究中取得了成功。在本文中，我们总结了阿片类药物成瘾的生物学机制和药物治疗，并回顾了有关阿片类药物成瘾的遗传学、预测阿片类药物成瘾风险的有希望的方法以及一种新的基因编辑方法的文章。需要进一步研究基于个体脆弱性的医学治疗方法。 GWAS；药物治疗;丁丙诺啡；美沙酮；纳洛酮；阿片类药物成瘾；阿片类药物依赖；阿片受体；多基因风险评分。

神经及精神疾病及其并发征、合并征国际数据库描述：

Opioid addiction is a chronic and complex disease characterized by relapse and remission. In the past decade, the opioid epidemic or opioid crisis in the United States has raised public awareness. Methadone, buprenorphine, and naloxone have proven their effectiveness in treating addicted individuals, and each of them has different effects on different opioid receptors. Classic and molecular genetic research has provided valuable information and revealed the possible mechanism of individual differences in vulnerability for opioid addiction. The polygenic risk score based on the results of a genome-wide association study (GWAS) may be a promising tool to evaluate the association between phenotypes and genetic markers across the entire genome. A novel gene editing approach, clustered, regularly-interspaced short palindromic repeats (CRISPR), has been widely used in basic research and potentially applied to human therapeutics such as mental illness; many applications against addiction based on CRISPR are currently under research, and some are successful in animal studies. In this article, we summarized the biological mechanisms of opioid addiction and medical treatments, and we reviewed articles about the genetics of opioid addiction, the promising approach to predict the risk of opioid addiction, and a novel gene editing approach. Further research on medical treatments based on individual vulnerability is needed.Keywords: CRISPR; GWAS; Medical treatment; buprenorphine; methadone; naloxone; opioid addiction; opioid dependence; opioid receptors; polygenic risk score.