【佳学基因检测】维生素 D 状态和 VDR 多态性基因检测预测分化型甲状腺癌的治疗效果

肿瘤基因检测的费用大概多少钱引言

研究癌症的早期发现及检测获悉《In Vivo》在. 2022 Sep-Oct;36(5):2434-2441.发表了一篇题目为《维生素 D 状态和 VDR 多态性基因检测预测分化型甲状腺癌的治疗效果》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Andra-Maria Cocolos, Andrei Muresan, Andra Caragheorgheopol, Mircea Ghemigian, Dumitru Ioachim, Catalina Poiana等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

25OH维生素D,FokI,甲状腺癌, VDR 多态性,维生素D

肿瘤靶向治疗基因检测临床应用结果

甲状腺癌治疗效果基因检测的背景/目的：维生素 D 缺乏和维生素 D 受体 (VDR) 基因多态性参与多种生物学过程，包括恶性肿瘤中的细胞增殖、凋亡和粘附。甲状腺癌治疗效果基因检测研究调查了维生素 D 水平和 VDR 的基因序列差异性是否是甲状腺癌的危险因素。同时测量了 VDR 基因多态性（ApaI、TaqI、FokI 和 BsmI）及其 25(OH)D 水平。还获得了所有患者的大人群统计学数据和组织病理学报告。甲状腺癌治疗效果基因检测的结果：甲状腺癌组的维生素 D 水平显着降低 (p=0.03)。 FokI 和 TaqI 多态性在甲状腺癌患者基因检测结果中更为常见（p<0.001）。与对照组相比，甲状腺癌患者中 FokI Ff 基因型的比例增加（p<0.0006），TaqI Tt 基因型的比例也更高（p<0.0001）。 FokI的Ff基因型也与多灶性甲状腺癌、侵袭模式和局部转移风险相关。甲状腺癌治疗效果基因检测的结论：VDR基因FokI的多态性基因检测可能与甲状腺癌及其更具侵袭性的风险相关。关键词：25OH维生素D；FokI；甲状腺癌; VDR 多态性；维生素D。

肿瘤发生与反复转移国际数据库描述：

Background/aim: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer.Patients and methods: Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.Results: Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p<0.001). Compared to control, the proportion of the FokI Ff genotype was increased (p<0.0006) and the proportion of the TaqI Tt genotype was also higher among patients with thyroid cancer (p<0.0001). The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis.Conclusion: The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.Keywords: 25OHvitamin D; FokI; Thyroid cancer; VDR polymorphisms; vitamin D.