【佳学基因检测】CHRM1基因测试有突变会得什么病？

基因检测的序列名称：

CHRM1

人体基因序列变化与疾病表征数据库中的基因代码：

1128

人体基因序列数据库中国际交流名称全称

cholinergic receptor muscarinic 1

中国数据库中基因全称：

胆碱能受体毒蕈碱1

基因检测报告英文版基因简介

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

基因突变所影响的基因信息

毒蕈碱胆碱能受体属于更大的G蛋白偶联受体家族。这些受体的功能多样性由乙酰胆碱的结合决定，包括细胞反应，例如腺苷酸环化酶抑制，磷酸肌醇变性和钾通道介导。毒蕈碱受体影响乙酰胆碱在中枢神经系统和周围神经系统中的多种作用。毒蕈碱胆碱能受体1参与介导阴道诱发的支气管收缩和胃肠道酸分泌。编码该受体的基因位于11q13。[由RefSeq提供，2008年7月]

国际国内该碱基基因序列的其他英语文字母简称：

HM1, M1, M1R

基因解码对该基因序列在细胞核中的染色体所给予的编号：

该基因序列位于人类第11号染色体上。

基因解码对基因序列的正确定位

该基因序列在GRCh37版本中的起始位置坐标为：62676151；结束位置坐标为：62689012。该基因序列在GRCh38版本中的起始位置坐标为：62908675；结束位置坐标为：62921861。正确的基因信息定位是基因检测和对检测结果进行正确解读的关键。

佳学基因解码对该基因的功能分类：国际版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解码对该基因的功能分类：中文版

G 蛋白偶联受体/GPCR 不包括嗅觉受体

结构与功能基因解码所揭示的该基因在细胞内发挥作用的场所（国际版）：

Cytosol;Nucleus

结构与功能基因解码所揭示的该基因发挥作用的细胞内位置（中文版）：

胞质溶胶；细胞核

该基因序列变化后增加的疾病风险（国际版）：

Chronic schizophrenia; Memory Disorders; Brain Ischemia; Epilepsy; Seizures; Schizophrenia

如果该基因突变后，风险可能增加的疾病类型（中文版）：

慢性精神分裂症；记忆障碍；脑缺血；癫痫;癫痫发作；精神分裂症

GWAS基因检测所建立的与该基因的疾病关联（国际版）：

正在通过基因解码技术进行收集、查证并编辑，请关注佳学基因，获得及时更新的人类基因序列变化与疾病表征数据库的更新内容

GWAS基因检测所解码的该基因突变会增加风险的疾病种类（中文版）：

正在通过基因解码技术进行收集、查证并编辑，请关注佳学基因，获得及时更新的人类基因序列变化与疾病表征数据库的更新内容

以该基因做靶点的药物（国际版）：

Cevimeline (Phosphatidylinositol phospholipase c activity);Succinylcholine (Phosphatidylinositol phospholipase c activity);Trospium (Phosphatidylinositol phospholipase c activity);Citalopram (Phosphatidylinositol phospholipase c activity);Oxyphenonium (Phosphatidylinositol phospholipase c activity);Benzatropine (Phosphatidylinositol phospholipase c activity);Ziprasidone (Phosphatidylinositol phospholipase c activity);Disopyramide (Phosphatidylinositol phospholipase c activity);Amitriptyline (Phosphatidylinositol phospholipase c activity);Ipratropium bromide (Phosphatidylinositol phospholipase c activity);Olanzapine (Phosphatidylinositol phospholipase c activity);Metixene (Phosphatidylinositol phospholipase c activity);Terfenadine (Phosphatidylinositol phospholipase c activity);Buclizine (Phosphatidylinositol phospholipase c activity);Clozapine (Phosphatidylinositol phospholipase c activity);Doxylamine (Phosphatidylinositol phospholipase c activity);Trihexyphenidyl (Phosphatidylinositol phospholipase c activity);Oxyphencyclimine (Phosphatidylinositol phospholipase c activity);Procyclidine (Phosphatidylinositol phospholipase c activity);Ethopropazine (Phosphatidylinositol phospholipase c activity);Loxapine (Phosphatidylinositol phospholipase c activity);Carbachol (Phosphatidylinositol phospholipase c activity);Promazine (Phosphatidylinositol phospholipase c activity);Hyoscyamine (Phosphatidylinositol phospholipase c activity);Cyproheptadine (Phosphatidylinositol phospholipase c activity);Pethidine (Phosphatidylinositol phospholipase c activity);Imipramine (Phosphatidylinositol phospholipase c activity);Methylscopolamine bromide (Phosphatidylinositol phospholipase c activity);Chlorpromazine (Phosphatidylinositol phospholipase c activity);Darifenacin (Phosphatidylinositol phospholipase c activity);Tridihexethyl (Phosphatidylinositol phospholipase c activity);Triflupromazine (Phosphatidylinositol phospholipase c activity);Anisotropine Methylbromide (Phosphatidylinositol phospholipase c activity);Nortriptyline (Phosphatidylinositol phospholipase c activity);Amoxapine (Phosphatidylinositol phospholipase c activity);Amoxapine (Phosphatidylinositol phospholipase c activity);Cinnarizine (Phosphatidylinositol phospholipase c activity);Atropine (Phosphatidylinositol phospholipase c activity);Nicardipine (Phosphatidylinositol phospholipase c activity);Pirenzepine (Phosphatidylinositol phospholipase c activity);Paroxetine (Phosphatidylinositol phospholipase c activity);Homatropine Methylbromide (Phosphatidylinositol phospholipase c activity);Trimipramine (Phosphatidylinositol phospholipase c activity);Scopolamine (Phosphatidylinositol phospholipase c activity);Benzquinamide (Phosphatidylinositol phospholipase c activity);Clidinium (Phosphatidylinositol phospholipase c activity);Propiomazine (Phosphatidylinositol phospholipase c activity);Propantheline (Phosphatidylinositol phospholipase c activity);Cryptenamine (Phosphatidylinositol phospholipase c activity);Dicyclomine (Phosphatidylinositol phospholipase c activity);Minaprine (Phosphatidylinositol phospholipase c activity);Tropicamide (Phosphatidylinositol phospholipase c activity);Biperiden (Phosphatidylinositol phospholipase c activity);Brompheniramine (Phosphatidylinositol phospholipase c activity);Flupentixol (Phosphatidylinositol phospholipase c activity);Cocaine (Phosphatidylinositol phospholipase c activity);Maprotiline (Phosphatidylinositol phospholipase c activity);Methantheline (Phosphatidylinositol phospholipase c activity);Cycrimine (Phosphatidylinositol phospholipase c activity);Cyclopentolate (Phosphatidylinositol phospholipase c activity);Glycopyrronium (Phosphatidylinositol phospholipase c activity);Tolterodine (Phosphatidylinositol phospholipase c activity);Oxybutynin (Phosphatidylinositol phospholipase c activity);Promethazine (Phosphatidylinositol phospholipase c activity);Pilocarpine (Phosphatidylinositol phospholipase c activity);Doxepin (Phosphatidylinositol phospholipase c activity);Flavoxate (Phosphatidylinositol phospholipase c activity);Desipramine (Phosphatidylinositol phospholipase c activity);Escitalopram (Phosphatidylinositol phospholipase c activity);Ketamine (Phosphatidylinositol phospholipase c activity);Quetiapine (Phosphatidylinositol phospholipase c activity);Diphenidol (Phosphatidylinositol phospholipase c activity);Metoclopramide (Phosphatidylinositol phospholipase c activity);Aripiprazole (Phosphatidylinositol phospholipase c activity);Chlorprothixene (Phosphatidylinositol phospholipase c activity);Methotrimeprazine (Phosphatidylinositol phospholipase c activity);Tiotropium (Phosphatidylinositol phospholipase c activity);Solifenacin (Phosphatidylinositol phospholipase c activity);Molindone (Phosphatidylinositol phospholipase c activity);Arecoline (Phosphatidylinositol phospholipase c activity);Mepenzolate (Phosphatidylinositol phospholipase c activity);NGX267 (Phosphatidylinositol phospholipase c activity);ALKS 27 (Phosphatidylinositol phospholipase c activity);ACP-104 (Phosphatidylinositol phospholipase c activity);Fesoterodine (Phosphatidylinositol phospholipase c activity);Aclidinium (Phosphatidylinositol phospholipase c activity);Umeclidinium (Phosphatidylinositol phospholipase c activity)

针对该基因所产生的突变，可能有正确效果的药物（中文版）：

Cevimeline（磷脂酰肌醇磷脂酶 c 活性）；琥珀酰胆碱（磷脂酰肌醇磷脂酶 c 活性）；Trospium（磷脂酰肌醇磷脂酶 c 活性）；西酞普兰（磷脂酰肌醇磷脂酶 c 活性）；氧酚（磷脂酰肌醇磷脂酶 c 活性）；苯扎托品（Phos磷脂酰肌醇磷脂酶 c 活性）；齐拉西酮（磷脂酰肌醇磷脂酶 c 活性);丙吡胺（磷脂酰肌醇磷脂酶 c 活性）;阿米替林（磷脂酰肌醇磷脂酶 c 活性）;异丙托溴铵（磷脂酰肌醇磷脂酶 c 活性）;奥氮平（磷脂酰肌醇磷脂酶 c 活性）;Metixene（磷脂酰肌醇itol 磷脂酶 c 活性）；特非那定（磷脂酰肌醇磷脂酶 c 活性）；布克利嗪（磷脂酰肌醇磷脂酶 c 活性）；氯氮平（磷脂酰肌醇磷脂酶 c 活性）；多西拉敏（磷脂酰肌醇磷脂酶 c 活性）；苯海索（磷脂酰肌醇磷脂酶 c 活性）；羟苯环亚胺（磷脂酰肌醇磷脂酶 c 活性）活动）；丙环定（磷脂酰肌醇磷脂酶 c乙丙嗪（磷脂酰肌醇磷脂酶 c 活性）；洛沙平（磷脂酰肌醇磷脂酶 c 活性）；卡巴胆碱（磷脂酰肌醇磷脂酶 c 活性）；异丙嗪（磷脂酰肌醇磷脂酶 c 活性）；天仙子胺（磷脂酰肌醇磷脂酶 c 活性）；赛庚啶（磷脂酰肌醇磷脂酶 c 活性） ;哌替啶（磷脂酰肌醇磷脂酶 c 活性）；丙咪嗪（磷脂酰肌醇磷脂酶 c 活性）；甲基东莨菪碱溴化物（磷脂酰肌醇磷脂酶 c 活性）；氯丙嗪（磷脂酰肌醇磷脂酶 c 活性）；达非那新（磷脂酰肌醇磷脂酶 c 活性）；Tridihe xethyl（磷脂酰肌醇磷脂酶 c 活性）；三氟丙嗪（磷脂酰肌醇磷脂酶 c 活性）；异丙嗪甲基溴（磷脂酰肌醇磷脂酶 c 活性）；去甲替林（磷脂酰肌醇磷脂酶 c 活性）；阿莫沙平（磷脂酰肌醇磷脂酶 c 活性）；阿莫沙平（磷脂酰肌醇磷脂酶 c 活性）；Cin桂利嗪（磷脂酰肌醇磷脂酶 c 活性）；阿托品（磷脂酰肌醇磷脂酶 c 活性）；尼卡地平（磷脂酰肌醇磷脂酶 c 活性）；哌仑西平（磷脂酰肌醇磷脂酶 c 活性）；帕罗西汀（磷脂酰肌醇磷脂酶 c 活性）；后马托品甲基溴（磷脂酰肌醇磷脂酶 c 活性）；曲米帕明（磷脂酰肌醇磷脂酶 c 活性）磷脂酰肌醇磷脂酶 c 活性）；东莨菪碱（磷脂酰肌醇磷脂酶 c 活性）；Benzquinamide（磷脂酰肌醇磷脂酶 c 活性）；Clidinium（磷脂酰肌醇磷脂酶 c 活性）；Propiomazine（磷脂酰肌醇磷脂酶 c 活性）；Propantheline（磷脂酰肌醇磷脂酶 c 活性）；Cryptenamine（磷脂酰肌醇磷酸酶）脂肪酶 c 活性）；双环胺（磷脂酰肌醇磷脂酶c活性);米那普林(磷脂酰肌醇磷脂酶c活性);托吡卡胺(磷脂酰肌醇磷脂酶c活性);比哌立登(磷脂酰肌醇磷脂酶c活性);溴苯那敏(磷脂酰肌醇磷脂酶c活性);氟哌噻吨(磷脂酰肌醇磷脂酶c活性);可卡因(磷脂磷脂酰肌醇磷脂酶c活性);马普替林（磷脂酰肌醇磷脂酶 c 活性）;美沙林（磷脂酰肌醇磷脂酶 c 活性）;环辛胺（磷脂酰肌醇磷脂酶 c 活性）;环喷托酯（磷脂酰肌醇磷脂酶 c 活性）;格隆铵（磷脂酰肌醇磷脂酶 c 活性）;托特罗定（磷脂酰肌醇磷脂酶 c 活性）；奥昔布宁（磷脂酰肌醇磷脂酶 c 活性）；异丙嗪（磷脂酰肌醇磷脂酶 c 活性）；毛果芸香碱（磷脂酰肌醇磷脂酶 c 活性）；多塞平（磷脂酰肌醇磷脂酶 c 活性）；黄酮（磷脂酰肌醇磷脂酶 c 活性）；地昔帕明（磷脂酰肌醇磷脂酰肌醇磷脂酶 c 活性）；艾司西酞普兰（磷脂酰肌醇磷脂酶c活性);氯胺酮(磷脂酰肌醇磷脂酶c活性);喹硫平(磷脂酰肌醇磷脂酶c活性);地苯尼多(磷脂酰肌醇磷脂酶c活性);甲氧氯普胺(磷脂酰肌醇磷脂酶c活性);阿立哌唑(磷脂酰肌醇c活性)磷脂酶 c 活性）；氯丙噻吩（磷脂酰肌醇磷脂酶c活性);甲氧美拉嗪(磷脂酰肌醇磷脂酶c活性);噻托溴铵(磷脂酰肌醇磷脂酶c活性);索利那新(磷脂酰肌醇磷脂酶c活性);吗啉酮(磷脂酰肌醇磷脂酶c活性);槟榔碱(磷脂酰肌醇磷脂酶c活性);甲哌佐酯(P磷脂酰肌醇磷脂酶c活性);NGX267（磷脂酰肌醇磷脂酶 c 活性）;ALKS 27（磷脂酰肌醇磷脂酶 c 活性）;ACP-104（磷脂酰肌醇磷脂酶 c 活性）;非索罗定（磷脂酰肌醇磷脂酶 c 活性）;阿地铵（磷脂酰肌醇磷脂酶 c 活性）;乌美克定ium（磷脂酰肌醇磷脂酶 c活动）