【佳学基因检测】寻找癌症易感性遗传变异的关联研究

肿瘤基因疗法说明

开会学习《肿瘤基因突变度与预防策略的实施计划》《Nat Rev Cancer》在 2004 Nov;4(11):850-60发表了一篇题目为《寻找癌症易感性遗传变异的关联研究》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Paul D P Pharoah, Alison M Dunning, Bruce A J Ponder, Douglas F Easton等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

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肿瘤靶向治疗基因检测临床应用结果

癌症是遗传因素和环境因素之间复杂相互作用的结果。已知基因占癌症遗传力的一小部分，很可能还有许多具有适度影响的基因尚未被发现。遗传关联研究已广泛用于寻找此类基因，但迄今为止成功有限。对基因功能和人类遗传变异结构的了解增加，再加上新的基因分型技术，预示着通过关联进行基因作图的新时代。

肿瘤发生与反复转移国际数据库描述：

Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.