【佳学基因检测】癌症基因治疗中的腺相关病毒 (AAV) 载体

肿瘤基因检测19800元导读

根据肿瘤治疗的前沿研究知道《J Control Release》在. 2016 Oct 28;240:287-301.发表了一篇题目为《癌症基因治疗中的腺相关病毒 (AAV) 载体》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Jorge L Santiago-Ortiz, David V Schaffer等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

细胞凋亡,结直肠癌,转移,微小RNA,多药耐药,预后,反复,风险分层,治疗目标

肿瘤靶向治疗基因检测临床应用结果

基于腺相关病毒 (AAV) 的基因递送载体已被用于大量基因治疗临床试验，这些试验证明了其强大的安全性和越来越多的治疗单基因疾病的疗效。对于癌症应用，AAV 载体已被用于向临床前模型以及贼近涉及某些癌症的临床试验提供广泛的转基因库。这篇综述描述了 AAV 载体在癌症模型中的应用，并介绍了载体工程和有效载荷设计的发展，旨在定制 AAV 载体以转导和治疗癌细胞。基因解码基因检测还讨论了 AAV 在肿瘤学中的临床发展现状以及 AAV 在该领域的未来发展方向。腺相关病毒；癌症;基因传递；基因传递载体；基因治疗。关键词：EIF2B5；入侵；转移;甲基化；卵巢癌;增殖; lncRNA KCNQ1OT1。

肿瘤发生与反复转移国际数据库描述：

Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For cancer applications, AAV vectors have been harnessed for delivery of an extensive repertoire of transgenes to preclinical models and, more recently, clinical trials involving certain cancers. This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells. We also discuss the current status of AAV clinical development in oncology and future directions for AAV in this field.Keywords: AAV; Adeno-associated virus; Cancer; Gene delivery; Gene delivery vectors; Gene therapy.Keywords: EIF2B5; Invasion; Metastasis; Methylation; Ovarian cancer; Proliferation; lncRNA KCNQ1OT1.