【佳学基因检测】解密ADRB1基因检测结果，如何指导一个的健康？

基因检测的序列名称：

ADRB1

人体基因序列变化与疾病表征数据库中的基因代码：

153

人体基因序列数据库中国际交流名称全称

adrenoceptor beta 1

中国数据库中基因全称：肾上腺素受体1基因检测报告英文版基因简介

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

基因突变所影响的基因信息

肾上腺素受体（亚型α1，α2，β1和β2）是鸟嘌呤核苷酸结合调节蛋白偶联受体的原型家族，其介导激素肾上腺素和神经递质去甲肾上腺素的生理作用。该基因的特定多态性已显示会影响静息心率，并可能与心力衰竭有关。[由RefSeq提供，2008年7月]

国际国内该碱基因序列的其他英语文字母简称：

ADRB1R, B1AR, BETA1AR, RHR

基因解码对该基因序列在细胞核中的染色体所给予的编号：

该基因序列位于人类第10号染色体上。

基因解码对基因序列的正确定位

该基因序列在GRCh37版本中的起始位置坐标为：115803806；结束位置坐标为：115806667。该基因序列在GRCh38版本中的起始位置坐标为：114044047；结束位置坐标为：114046908。正确的基因信息定位是基因检测和对检测结果进行正确解读的关键。

佳学基因解码对该基因的功能分类：国际版

G-protein coupled receptors/GPCRs excl olfactory receptors;Transporters

基因解码对该基因的功能分类：中文版

G 蛋白偶联受体/GPCR，不包括嗅觉受体；转运体

结构与功能基因解码所揭示的该基因在细胞内发挥作用的场所（国际版）：

正在通过基因解码技术进行收集、查证并编辑，请关注佳学基因，获得及明更新的人类基因序列变化与疾病表征数据库的更新内容

结构与功能基因解码所揭示的该基因发挥作用的细胞内位置（中文版）：

正在通过基因解码技术进行收集、查证并编辑，请关注佳学基因，获得及明更新的人类基因序列变化与疾病表征数据库的更新内容

该基因序列变化后增加的疾病风险（国际版）：

Ventricular Dysfunction; Endomyocardial Fibrosis; Hyperemia; Birth Weight; Cardiovascular Diseases; Cardiomyopathy, Dilated; Myocardial Reperfusion Injury; Diabetes Mellitus; Heart failure; Myocardial Ischemia; Mood Disorders; Mental Depression; Obesity; Hypertensive disease; Stomach Neoplasms; Depressive disorder

如果该基因突变后，风险可能增加的疾病类型（中文版）：

心室功能障碍；心内膜心肌纤维化；充血;出生体重;心血管疾病;心肌病扩张型；心肌再灌注损伤；糖尿病；心脏衰竭;心肌缺血；情绪障碍；精神抑郁症；肥胖;高血压病；胃肿瘤；抑郁症

GWAS基因检测所建立的与该基因的疾病关联（国际版）：

Gaucher Disease;Blood Pressure

GWAS基因检测所解码的该基因突变会增加风险的疾病种类（中文版）：

戈谢病；血压

以该基因做靶点的药物（国际版）：

Amphetamine (Receptor signaling protein activity);Esmolol (Receptor signaling protein activity);Betaxolol (Receptor signaling protein activity);Bethanidine (Receptor signaling protein activity);Isoetarine (Receptor signaling protein activity);Cabergoline (Receptor signaling protein activity);Metoprolol (Receptor signaling protein activity);Amitriptyline (Receptor signaling protein activity);Olanzapine (Receptor signaling protein activity);Atenolol (Receptor signaling protein activity);Norepinephrine (Receptor signaling protein activity);Mirtazapine (Receptor signaling protein activity);Timolol (Receptor signaling protein activity);Phenylpropanolamine (Receptor signaling protein activity);Loxapine (Receptor signaling protein activity);Sotalol (Receptor signaling protein activity);Carteolol (Receptor signaling protein activity);Nortriptyline (Receptor signaling protein activity);Propranolol (Receptor signaling protein activity);Labetalol (Receptor signaling protein activity);Bisoprolol (Receptor signaling protein activity);Epinephrine (Receptor signaling protein activity);Trimipramine (Receptor signaling protein activity);Dobutamine (Receptor signaling protein activity);Pseudoephedrine (Receptor signaling protein activity);Alprenolol (Receptor signaling protein activity);Pindolol (Receptor signaling protein activity);Salbutamol (Receptor signaling protein activity);Isoprenaline (Receptor signaling protein activity);Arbutamine (Receptor signaling protein activity);Amiodarone (Receptor signaling protein activity);Carvedilol (Receptor signaling protein activity);Desipramine (Receptor signaling protein activity);Acebutolol (Receptor signaling protein activity);Nadolol (Receptor signaling protein activity);Levobunolol (Receptor signaling protein activity);Metipranolol (Receptor signaling protein activity);Fenoterol (Receptor signaling protein activity);Pirbuterol (Receptor signaling protein activity);Bevantolol (Receptor signaling protein activity);Practolol (Receptor signaling protein activity);Penbutolol (Receptor signaling protein activity);Ephedra (Receptor signaling protein activity);Mephentermine (Receptor signaling protein activity);Clenbuterol (Receptor signaling protein activity);Oxprenolol (Receptor signaling protein activity);Celiprolol (Receptor signaling protein activity);Dronedarone (Receptor signaling protein activity);Nebivolol (Receptor signaling protein activity);Asenapine (Receptor signaling protein activity);Droxidopa (Receptor signaling protein activity);Bufuralol (Receptor signaling protein activity);4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile (Receptor signaling protein activity);2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL (Receptor signaling protein activity);Bopindolol (Receptor signaling protein activity);Bupranolol (Receptor signaling protein activity);Vortioxetine (Receptor signaling protein activity)

针对该基因所产生的突变，可能有正确效果的药物（中文版）：

安非他明（受体信号蛋白活性）;艾司洛尔（受体信号蛋白活性）;倍他洛尔（受体信号蛋白活性）;Bethanidine（受体信号蛋白活性）;异乙他林（受体信号蛋白活性）;卡麦角林（受体信号蛋白活性）;美托洛尔（受体信号蛋白活性);阿米替林(受体信号蛋白活性);奥氮平(受体信号蛋白活性);阿替洛尔(受体信号蛋白活性);去甲肾上腺素(受体信号蛋白活性);米氮平(受体信号蛋白活性);噻吗洛尔(受体信号蛋白活性)蛋白活性);苯丙醇胺(受体信号蛋白活性);洛沙平(受体信号蛋白活性);索他洛尔(受体信号蛋白活性);卡替洛尔(受体信号蛋白活性);去甲替林(受体信号蛋白活性);普萘洛尔(受体信号蛋白活性) );拉贝洛尔（受体信号蛋白活性）;比索洛尔（受体信号蛋白活性）;肾上腺素（受体信号蛋白活性）;曲米帕明（受体信号蛋白活性）;多巴酚丁胺（受体信号蛋白活性）;伪麻黄碱（受体信号蛋白活性）; Alprenolol (Receptor signaling protein activity);吲哚洛尔(Receptor signaling protein activity);沙丁胺醇(Salbutamol)(Receptor signaling protein activity);异丙肾上腺素(Isoprenaline)(Receptor signaling protein activity);Arbutamine (Receptor signaling protein activity);胺碘酮(Receptor signaling protein activity);卡维地洛(Carvedilol)受体信号蛋白活性);地昔帕明(受体信号蛋白活性);醋丁洛尔(受体信号蛋白活性);纳多洛尔(受体信号蛋白活性);左布洛尔(受体信号蛋白活性);美替洛尔(受体信号蛋白活性);非诺特罗(受体信号蛋白活性)蛋白活性);吡布特罗(受体信号蛋白活性);Bevantolol(受体信号蛋白活性);Practolol(受体信号蛋白活性);喷布洛尔(受体信号蛋白活性);麻黄(受体信号蛋白活性);美芬特明(受体信号蛋白活性) );瘦肉精（受体信号蛋白活性）;氧烯洛尔（受体信号蛋白活性）;赛力洛尔（受体信号蛋白活性）;决奈达隆（受体信号蛋白活性）;奈必洛尔（受体信号蛋白活性）;阿塞那平（受体信号蛋白活性）;屈昔多巴（受体信号蛋白活性）；丁呋洛尔（受体信号蛋白活性）；4-{[(2S)-3-(叔丁基氨基)-2-羟丙基]氧基}-3H-吲哚-2-腈（受体信号蛋白activity);2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL (Receptor signaling protein activity);Bopindolol (Receptor signaling protein activity);Bupranolol (Receptor signaling protein activity);Vortioxetine (Receptor signaling protein activity)活动）